Log out
My profile and settings
My bookmarks
Comment history
Please complete your account verification. Resend verification email.
today
This verification token has expired.
today
Your email address has been verified. Update my profile.
today
Your account has been deactivated. Sign in to re-activate your account.
today
View all newsletters in the newsletter archive
today
You are now unsubscribed from receiving emails.
today
Sorry, we were unable to unsubscribe you at this time.
today
0
0
Back to profile
Comment Items
You have not left any comments yet.
title
you replied to a comment:
name
description
Saved Posts
You haven’t bookmarked any posts yet.

When you see good things happening, you can channel your energy into driving even more progress.

Read Post
Become a Gates Notes Insider
Sign up
Log out
Personal Information
Title
Mr
Mrs
Ms
Miss
Mx
Dr
Cancel
Save
This email is already registered
Cancel
Save
Please verify email address. Click verification link sent to this email address or resend verification email.
Cancel
Save
Email and Notification Settings
Send me updates from Bill Gates
You must provide an email
On
Off
Send me Gates Notes survey emails
On
Off
Send me the weekly Top of Mind newsletter
On
Off
Email me comment notifications
On
Off
On-screen comment notifications
On
Off
Interests
Select interests to personalize your profile and experience on Gates Notes.
Saving Lives
Energy Innovation
Improving Education
Alzheimer's
Philanthropy
Book Reviews
About Bill Gates
Account Deactivation
Click the link below to begin the account deactivation process.
If you would like to permanently delete your Gates Notes account and remove it’s content, please send us a request here.

Know your enemy

The U.S. military versus the mosquito

Finding ways to protect soldiers from mosquitoes is a top priority at the Walter Reed Army Institute of Research.

|
0

The most dangerous foe U.S. soldiers may have ever encountered is the mosquito, which has caused more casualties than bombs or bullets during the nation’s conflicts.

One of the first military expenditures by the Continental Congress was $300 for quinine to protect General George Washington’s troops from malaria. During the Civil War, there were over a million cases of malaria in Union troops alone. In World War II, there were nearly 700,000 cases of malaria. In Vietnam, 50,000 cases. And more recently, of all the American soldiers deployed in Afghanistan, one out of every 20 of them battled malaria.

Finding ways to protect soldiers from the mosquito—the world’s deadliest animal—is a top priority at the U.S. Department of Defense’s Walter Reed Army Institute of Research (WRAIR).

I expect most people have never heard about WRAIR—or, if they have, they may be confusing it with the more familiar but separate institution, the Walter Reed National Military Medical Center, where U.S. presidents visit wounded troops and go for medical treatment.

It’s too bad more people don’t know about the work being done at WRAIR. Since its founding in 1893, WRAIR has been a global research leader into new malaria drugs, mosquito control, and more recently, vaccines, to protect people from mosquito-borne diseases. This research benefits the lives of not only American soldiers, but also billions of people living in areas where mosquito-borne diseases are a threat. That’s why our foundation collaborates with WRAIR on a range of research projects in malaria and other diseases that endanger the lives of people living in some of the world’s poorest areas.

Here’s one of many incredible facts that speak to WRAIR prominence in malaria research: WRAIR has contributed to the discovery and development of all FDA-approved malaria drugs, including primaquine, mefloquine, atovaquone/proguanil (Malarone), tafenoquine, and doxycycline. If you’ve ever traveled to an area where malaria is prevalent you’ve probably been prescribed one of these drugs for protection. And because of the spread of malaria drug resistance, WRAIR continues to explore new drugs to stay one step ahead of this threat.

WRAIR, in partnership with the Smithsonian Institute, also manages the world’s largest mosquito collection, which currently has more than 1.7 million specimens. Some of the oldest were collected by Walter Reed, the Army major who helped discover that yellow fever is transmitted by mosquitoes. WRAIR is named in his honor.

This large mosquito collection allows WRAIR researchers to “know their enemy,” by giving them a deep understanding of the huge variety of mosquito species that populate the globe so they can mount the most effective defenses against them.

The first line of defense for soldiers is their clothing and WRAIR has developed uniforms treated with insecticides to protect them. Then, there are mosquito nets and various repellents, including ones that double as camouflage paint.

Highly effective vaccines against malaria and other mosquito-borne disease are also a priority at WRAIR. WRAIR developed the first-ever malaria vaccine in conjunction with GlaxoSmithKline. Researchers at WRAIR also led the development of a Zika vaccine.

One of the most surprising and important areas of research at WRAIR are the human malaria infection challenge trials. As part of this program, WRAIR recruits volunteers who agree to be bitten by malaria-infected mosquitoes, exposing themselves to a curable form of the disease to test the effectiveness of various interventions. This might sound scary, but the trials are extremely safe. The volunteers are carefully monitored and are quickly cured before they become too ill. In the last 30 years, WRAIR has performed over 100 trials on over 2,200 volunteers. Thanks to this research, WRAIR has greatly accelerated the development of experimental vaccines and malaria drugs.

What’s most exciting at WRAIR is the research that will help us all prepare for the threats of the future, including climate change, which will increase the spread of mosquito-borne diseases.

As Col. Brian Evans, WRAIR’s chief entomologist, says, “The challenge is always evolving and the role of WRAIR is to keep up with that, to stay ahead of the game.”

Thanks to their incredible work for more than 125 years, WRAIR has done just that.

Discussion
Thank you for being part of the Gates Notes Insider community.
Not seeing your comment? You can read our policy on moderating comments here and learn about our Gates Notes badges here.
Badge
📌
Pinned by
Gates Notes
Badge
ʼʼ
0 responses
Sort by
all
all
most
top
old
Comments loading...
CTW
Thanks for visiting the Gates Notes. We'd like your feedback.
Become a Gates Notes Insider
Join the Gates Notes community to access exclusive content, comment on stories, participate in giveaways, and more.
SIGN UP
Already have an account?
Log in here
Logout:


Become a Gates Notes Insider
Become a Gates Notes Insider
Join the Gates Notes community to get regular updates from Bill on key topics like global health and climate change, to access exclusive content, comment on stories, participate in giveaways, and more.
Already joined? Log in
Please send me updates from Breakthrough Energy on efforts to combat climate change.
On
Off
LOG IN
SIGN UP
Title
Mr
Mrs
Ms
Miss
Mx
Dr
This email is already registered. Enter a new email, try signing in or retrieve your password
Why are we collecting this information? Gates Notes may send a welcome note or other exclusive Insider mail from time to time. Additionally, some campaigns and content may only be available to users in certain areas. Gates Notes will never share and distribute your information with external parties.
Bill may send you a welcome note or other exclusive Insider mail from time to time. We will never share your information.
Sign up
We will never share or spam your email address. For more information see our Sign Up FAQ. By clicking "Sign Up" you agree to the Gates Notes Terms of Use / Privacy Policy.
Street address
City
postal_town
State Zip code
administrative_area_level_2
Country
Data
Gates Notes Insider Sign Up FAQ

Q. How do I create a Gates Notes account?

A. There are three ways you can create a Gates Notes account:

  • Sign up with Facebook. We’ll never post to your Facebook account without your permission.
  • Sign up with Twitter. We’ll never post to your Twitter account without your permission.
  • Sign up with your email. Enter your email address during sign up. We’ll email you a link for verification.

Q. Will you ever post to my Facebook or Twitter accounts without my permission?

A. No, never.

Q. How do I sign up to receive email communications from my Gates Notes account?

A. In Account Settings, click the toggle switch next to “Send me updates from Bill Gates.”

Q. How will you use the Interests I select in Account Settings?

A. We will use them to choose the Suggested Reads that appear on your profile page.

BACK
Forgot your password?
Enter the email you used to sign up and a reset password link will be sent to you.
This email is already registered. Enter a new email, try signing in or retrieve your password
Reset Password
Reset your password.
Set New Password
Your password has been reset. Please continue to the log in page.
Log in
Get emails from Bill Gates
Send me updates from Bill Gates
You must provide an email
On
Off
Email me comment notifications
On
Off
On-screen comment notifications
On
Off
This email is already registered
Finish
We will never share or spam your email address. For more information see our Sign up FAQ. By clicking "Continue" you agree to the Gates Notes Terms of Use / Privacy Policy.
You're in!
You're in!
Please check your email and click the link provided to verify your account.
Didn't get an email from us? Resend verification
Upload a profile picture
Choose image to upload
Uploading...
Uh Oh!
The image you are trying to upload is either too big or is an unacceptable format. Please upload a .jpg or .png image that is under 25MB.
Ok
Title
Mr
Mrs
Ms
Miss
Mx
Dr
Cancel
Save
This email is already registered
Cancel
Save
Please verify email address. Click verification link sent to this email address or resend verification email.
Email and notification settings
Send me updates from Bill Gates
You must provide an email
On
Off
Email me comment notifications
On
Off
On-screen comment notifications
On
Off
Select your interests
Saving Lives
Energy Innovation
Improving Education
Alzheimer's
Philanthropy
Book Reviews
About Bill Gates
Finish
Confirm Account Deactivation
Are you sure you want to deactivate your account?
Deactivating your account will unsubscribe you from Gates Notes emails, and will remove your profile and account information from public view on the Gates Notes. Please allow for 24 hours for the deactivation to fully process. You can sign back in at any time to reactivate your account and restore its content.
Deactivate My Acccount
Go Back
Your Gates Notes account has been deactivated.
Come back anytime.
Welcome back
In order to unsubscribe you will need to sign-in to your Gates Notes Insider account
Once signed in just go to your Account Settings page and set your subscription options as desired.
Sign In
Request account deletion
We’re sorry to see you go. Your request may take a few days to process; we want to double check things before hitting the big red button. Requesting an account deletion will permanently remove all of your profile content. If you’ve changed your mind about deleting your account, you can always hit cancel and deactivate instead.
Submit
Cancel
Thank You! Your request has been sent
Page https://www.gatesnotes.com:443/ secs = 0.0156256